Curcumin and hesperetin attenuate D-galactose-induced brain senescencein vitroandin vivo
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چکیده
منابع مشابه
Effect of curcumin on galactose-induced cataractogenesis in rats.
PURPOSE Curcumin, the active principle of turmeric, has been shown to have both antioxidant and hypoglycemic activity in vitro and in vivo. The purpose of this study was to investigate the effect of curcumin on the onset and maturation of galactose induced cataract. METHODS Sprague-Dawley rats (21 days old) were divided into 5 groups. The control group (A) received an AIN-93 diet, the galacto...
متن کاملSaponins from Aralia taibaiensis Attenuate D-Galactose-Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways
Reactive oxygen species (ROS) are closely related to the aging process. In our previous studies, we found that the saponins from Aralia taibaiensis have potent antioxidant activity, suggesting the potential protective activity on the aging. However, the protective effect of the saponins and the possible underlying molecular mechanism remain unknown. In the present study, we employed a D-galacto...
متن کاملProtective effect of crocin against d-galactose-induced aging in mice
Objective: Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice....
متن کاملCeftriaxone improves senile neurocognition damages induced by D-galactose in mice
Objective(s): Ceftriaxone (Cef), a beta-lactam antibiotic, is accompanied by antioxidant and anti-inflammatory properties. It has been shown that Cef has beneficial effects on Alzheimer’s disease. In the current investigation, the effect of Cef in a mice model of aging was investigated. Materials and Methods: Forty male mice were equally...
متن کامل[Effect of Boschniakia rossica extract on free radicals in brain of D-galactose induced senile rats].
OBJECTIVE To study the effect of Boschniakia rossica extract on free radicals in the brain of D-galactose induced senile rats. METHODS Sixty Wistar rats were randomly divided into normal group, model group (48 mg.kg(-1).d(-1) D-galactose, SC), Boschniakia rossica group (100, 150, 200 mg/kg ig and 48 mg.kg(-1).d(-1) D-galactose, SC). After 40 days, the activities of SOD, MAO and the content of...
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ژورنال
عنوان ژورنال: Nutrition Research and Practice
سال: 2020
ISSN: 1976-1457,2005-6168
DOI: 10.4162/nrp.2020.14.5.438